{"id":10714,"date":"2026-01-20T16:12:24","date_gmt":"2026-01-20T16:12:24","guid":{"rendered":"https:\/\/palynziqpatient-prod-001.azurewebsites.net\/en-us\/?page_id=10714"},"modified":"2026-04-08T09:54:44","modified_gmt":"2026-04-08T09:54:44","slug":"faqs","status":"publish","type":"page","link":"https:\/\/palynziq.biomarin.com\/en-us\/faqs\/","title":{"rendered":"FAQs"},"content":{"rendered":"
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Finding his rhythm and taking PALYNZIQ<\/p>\n <\/div>\n \n

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Frequently Asked Questions<\/h1>\n \n

Get answers to common questions about PALYNZIQ to decide with your doctor whether it\u2019s right for you or your loved one.<\/p>\n \n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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Find answers to questions that people have about PALYNZIQ<\/h3>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n
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What is\u00a0PALYNZIQ\u00a0and who is it for?\n<\/h2>\n <\/div>\n
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PALYNZIQ\u00ae (Pal-lin-zeek) (pegvaliase-pqpz) injection is a prescription medication used to lower blood levels of phenylalanine (Phe) in people 12 years and older with PKU (phenylketonuria) who have uncontrolled blood Phe levels above 600 micromol\/L (10 mg\/dL) on their current treatment. Your PALYNZIQ dose will be increased slowly so your body can get used to it.<\/p>\n <\/div>\n <\/div>\n

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How does\u00a0PALYNZIQ\u00a0work differently than other PKU treatments?\n<\/h2>\n <\/div>\n
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Most oral PKU medicines try to help\u00a0the\u00a0PAH enzyme work better. However, these medicines often do not work for people who have\u00a0very little\u00a0or no PAH\u00a0enzyme.<\/p>\n

PALYNZIQ\u00a0substitutes for\u00a0the\u00a0PAH enzyme that is missing or not working properly, so it can help no matter how little PAH enzyme you have.<\/p>\n

See what sets\u00a0PALYNZIQ apart<\/a><\/p>\n <\/div>\n <\/div>\n

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Does\u00a0PALYNZIQ\u00a0work for both classical and non-classical PKU?\n<\/h2>\n <\/div>\n
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PALYNZIQ is the first and only FDA-approved treatment that substitutes for the PAH enzyme. It is proven to lower Phe levels whether you have classical PKU or non-classical PKU, and does not require a restricted diet.<\/p>\n

See how PALYNZIQ works<\/a><\/p>\n <\/div>\n <\/div>\n

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Can I take\u00a0PALYNZIQ\u00a0without being on a\u00a0restricted diet?\n<\/h2>\n <\/div>\n
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Yes! PALYNZIQ is the first and only PKU treatment proven to lower Phe levels without requiring a restricted diet. In the clinical studies, most people did NOT consume a Phe-restricted diet while taking PALYNZIQ.<\/p>\n

A Phe-restricted diet is when people get over 75% of protein intake from medical food.<\/p>\n

Learn more about\u00a0diet flexibility<\/a><\/p>\n

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How can PALYNZIQ help teens and their caregivers?\n<\/h2>\n <\/div>\n
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Many teens struggle to stick with a restricted diet, which can lead to high Phe levels. Some families spend up to 19 hours per week and thousands in out-of-pocket costs per year caring for a child with PKU. PALYNZIQ may potentially support eligible teens while they build independence into adulthood.<\/p>\n

See PALYNZIQ results in teens ages 12\u201317<\/a><\/p>\n <\/div>\n <\/div>\n

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What was the effect of PALYNZIQ on Phe levels in the clinical studies?\n<\/h2>\n <\/div>\n
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With PALYNZIQ, both adults and teens lowered their Phe below expert-recommended levels.<\/p>\n

Check out the results<\/a><\/p>\n <\/div>\n <\/div>\n

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How can PALYNZIQ help me reach my treatment goals?\n<\/h2>\n <\/div>\n
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PALYNZIQ was specifically designed to work across PKU types to help people lower their Phe levels. If you have a goal in mind, PALYNZIQ can help.<\/p>\n

See what PALYNZIQ can offer<\/a><\/p>\n <\/div>\n <\/div>\n

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What should I know about PALYNZIQ side effects?\n<\/h2>\n <\/div>\n
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Some adults and teens taking PALYNZIQ experienced side effects during treatment. In studies, adults and teens had fewer of the 3 most common side effects as time passed. Discuss them with your clinic team and keep in mind that they are not all the possible side effects of PALYNZIQ. Call your doctor for medical advice about side effects.<\/p>\n

Understand the safety of PALYNZIQ<\/a><\/p>\n <\/div>\n <\/div>\n

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How\u00a0do you take\u00a0PALYNZIQ?\n<\/h2>\n <\/div>\n
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PALYNZIQ is a daily self-injection and is smaller than a flu shot. The first injection will be under the supervision of a healthcare provider. After that, you\u2019ll start by self-injecting PALYNZIQ once a week. Then, your clinic team will adjust your dose based on how you respond to treatment. Your PALYNZIQ dose will be increased slowly so your body can get used to it.<\/p>\n

Learn more about taking\u00a0PALYNZIQ<\/a><\/p>\n <\/div>\n <\/div>\n

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What should I know about anaphylaxis and PALYNZIQ?\n<\/h2>\n <\/div>\n
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PALYNZIQ can cause a severe allergic reaction (anaphylaxis) that may be life\u2060\u2013\u2060threatening and may happen any time during treatment.<\/strong> Severe allergic reactions are a serious and common side effect of PALYNZIQ. If you have a severe allergic reaction during treatment with PALYNZIQ, you will need to receive an immediate administration of epinephrine and get emergency medical help right away.<\/p>\n

If you have a severe allergic reaction, stop taking PALYNZIQ<\/strong> until you talk with your healthcare provider. Tell them that you had a severe allergic reaction. They will decide if it is safe for you to keep using it.<\/p>\n

Watch a video about managing anaphylaxis during treatment<\/a><\/p>\n <\/div>\n <\/div>\n \t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-10714","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nFAQs - BioMarin Palynziq Patient EN-US<\/title>\n<meta name=\"description\" content=\"Get answers to common questions about PALYNZIQ to decide with your doctor whether it\u2019s right for you or your loved one.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/palynziq.biomarin.com\/en-us\/faqs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FAQs\" \/>\n<meta property=\"og:description\" content=\"Get answers to common questions about PALYNZIQ to decide with your doctor whether it\u2019s right for you or your loved one.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/palynziq.biomarin.com\/en-us\/faqs\/\" \/>\n<meta property=\"og:site_name\" content=\"BioMarin Palynziq Patient EN-US\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-08T09:54:44+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/palynziq.biomarin.com\/en-us\/faqs\/\",\"url\":\"https:\/\/palynziq.biomarin.com\/en-us\/faqs\/\",\"name\":\"FAQs - 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