{"id":10697,"date":"2026-01-20T16:06:17","date_gmt":"2026-01-20T16:06:17","guid":{"rendered":"https:\/\/palynziqpatient-prod-001.azurewebsites.net\/en-us\/?page_id=10697"},"modified":"2026-04-02T12:59:38","modified_gmt":"2026-04-02T12:59:38","slug":"side-effects","status":"publish","type":"page","link":"https:\/\/palynziq.biomarin.com\/en-us\/side-effects\/","title":{"rendered":"Potential Side Effects"},"content":{"rendered":"<div id=\"acf-block-699ee4084f3d6\" class=\"hero pal-hero bg-white\">\n    <div class=\"hero-container\">\n        <div class=\"wrapper\">\n                            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/02\/251212_AL_PALYNZIQ_D1_01_Look_017-2-8.png?v=1.50);\"><\/div>\n                <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/02\/M-severe-allergic-reactions.png?v=1.50);\"><\/div>\n            \n                            <div class=\"attribution-tab\">\n                    <div class=\"attribution-image\">\n                        <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/KELSEY-nametag.svg?v=1.50\" alt=\"\" \/>                    <\/div>\n\n                    <p>Staying focused \u2028and taking PALYNZIQ<\/p>\n                <\/div>\n            \n            <div class=\"inner-wrapper\">\n                                    <div class=\"text-wrapper\">\n                                            <h1>SEVERE ALLERGIC REACTIONS CAN HAPPEN\u2014AND CAN BE MANAGED<\/h1>\n                    \n                                            <p>When you start treatment with PALYNZIQ, your immune system won\u2019t know what it is and may react to it. This reaction is called a \u201chypersensitivity event.\u201d<\/p>\n                    \n                                        <\/div>\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-69a70225155b8\" class=\"anchor-navigation\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                            <nav class=\"anchor-links\">\n                    <div class=\"down-arrow\"><\/div>\n                                                                        <div class=\"anchor-link\">\n                                <a href=\"#anaphylaxis-explained\" target=\"\"><p>Understanding Anaphylaxis<\/p>\n<\/a>\n                            <\/div>\n                                                                                                <div class=\"anchor-link\">\n                                <a href=\"#REMS\" target=\"\"><p>PALYNZIQ REMS Program<\/p>\n<\/a>\n                            <\/div>\n                                                                                                <div class=\"anchor-link\">\n                                <a href=\"#common\" target=\"\"><p>Common Side Effects<\/p>\n<\/a>\n                            <\/div>\n                                                            <\/nav>\n\n                <nav class=\"mobile-anchor-links\">\n                    <div class=\"down-arrow\"><\/div>\n                    <div class=\"form-item\">\n                        <label for=\"anchor-links-mobile\">Jump to:<\/label>\n                        <select class=\"text\" id=\"anchor-links-mobile\" name=\"anchor-links-mobile\">\n                            <option value=\"#\">Jump to:<\/option>\n                                                                                                <option value=\"#anaphylaxis-explained\"><p>Understanding Anaphylaxis<\/p>\n<\/option>\n                                                                                                                                <option value=\"#REMS\"><p>PALYNZIQ REMS Program<\/p>\n<\/option>\n                                                                                                                                <option value=\"#common\"><p>Common Side Effects<\/p>\n<\/option>\n                                                                                    <\/select>\n                    <\/div>\n                <\/nav>\n                    <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"anaphylaxis\" class=\"block wrapped-content bg-band bg-band-primary block-zero-top\" style=\"\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-699ee4084f9f5\" class=\"block-wysiwyg\">\n            <h2 style=\"text-align: center\">Understanding anaphylaxis<\/h2>\n<p style=\"text-align: center\">A severe allergic reaction (anaphylaxis) is a type of hypersensitivity event that may be life-threatening and can happen at any time during treatment with PALYNZIQ.<\/p>\n    <\/div>\n\n<figure id=\"acf-block-699ee5ca2cb5e\">\n    <div class=\"image image-responsive image-rounded image-natural-size image-align-center\">\n                    <div class=\"image-desktop\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/Card-1-1.svg\" alt=\"\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"image-mobile\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/Card-2.svg\" alt=\"\" \/>\t\t\t<\/div>\n            <\/div>\n    <\/figure>\n\n\n<div id=\"acf-block-699ee4084fbe4\" class=\"popout-cta\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <div class=\"cta-container\">\n                                    <div class=\"popout-eyebrow\">\n                        <p>Did you know? <\/p>\n\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/02\/light-bulb.svg?v=1.50\" alt=\"\" \/>                                            <\/div>\n                \n                                <div class=\"cta-content\">\n                    <p>Everyone who had a severe allergic reaction recovered,\u2028and <span class=\"alt\">NONE OF THEM HAD ANY LASTING PROBLEMS.<\/span><\/p>\n                <\/div>\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-699ee4084fc33\" class=\"block wrapped-content block-zero-bottom\" style=\"\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-699ee4084fc5e\" class=\"block-wysiwyg\">\n            <h2>You should carry your epinephrine device with you at all times<\/h2>\n<p><strong>Your clinic team will prescribe an epinephrine device in case you experience a severe allergic reaction. They will also train you to recognize the signs of a severe allergic reaction so you can be prepared to manage it if it happens.<\/strong><\/p>\n    <\/div>\n\n<div id=\"acf-block-699ee40850ae6\" class=\"block split-content equal-bias bg-band bg-band-white block-zero-top block-zero-bottom block-remove-top-padding\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <p>The signs include:<\/p>\n<ul>\n<li>Fainting (passing out)<\/li>\n<li>Dizziness or lightheadedness<\/li>\n<li>Sudden confusion<\/li>\n<li>Trouble breathing or wheezing<\/li>\n<li>Chest discomfort or chest tightness<\/li>\n<li>Fast heart rate<\/li>\n<\/ul>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <p>&nbsp;<\/p>\n<ul>\n<li>Swelling of your face, lips, eyes, or tongue<\/li>\n<li>Throat swelling or tightness<\/li>\n<li>Flushed or red skin<\/li>\n<li>Skin rash, itching, or raised bumps on skin<\/li>\n<li>Nausea, vomiting, or diarrhea<\/li>\n<li>Losing control of urine or stools<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-699ee40850b25\" class=\"block-wysiwyg\">\n            <p><strong>Other allergic reactions can happen during treatment, including rash, itching, or swelling of the face, lips, eyes, or tongue. Call your clinic team right away if you experience any of these symptoms, or symptoms of a severe allergic reaction listed above.<\/strong><\/p>\n<p>Your clinic team may prescribe medicines to help reduce the symptoms of an allergic reaction.<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-699ee40850b69\" class=\"block wrapped-content bg-band bg-band-primary\" style=\"\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<figure id=\"acf-block-699ee5ca2cb5e\">\n    <div class=\"image image-responsive image-rounded image-natural-size image-align-center\">\n                    <div class=\"image-desktop\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/D-severe-allergies-clinical-studies-1.svg\" alt=\"severe-allergies-clinical-studies\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"image-mobile\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/M-severe-allergies-clinical-studies-1.svg\" alt=\"severe-allergies-clinical-studies\" \/>\t\t\t<\/div>\n            <\/div>\n    <\/figure>\n\n\n<div id=\"acf-block-699ee40851155\" class=\"pal-rounded-cta\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n            <div class=\"cta-container\">\n                                <div class=\"cta-icon\">\n                    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/02\/Layer_1-1.svg?v=1.50\" alt=\"\" \/>                <\/div>\n                \n                                <div class=\"cta-content\">\n                    <p><span class=\"alt\">REMEMBER:<\/span> If you do have a severe allergic reaction with PALYNZIQ, it doesn\u2019t mean it will happen again. You may still be able to take PALYNZIQ.<\/p>\n                <\/div>\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"anaphylaxis-explained\" class=\"block split-content equal-bias bg-band bg-band-white block-zero-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                <div class=\"video-poster\">\n\t\t\t                            <a class=\"modal-video permitted\" href=\"https:\/\/player.vimeo.com\/video\/713565078\" style=\"background-image: url(https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2023\/11\/Anaphylaxis_img.jpg?v=1.50);\">Play<\/a>\n\t\t                            <\/div>\n                                    \n                                                                                                                    \n                                                                                                                \n\t\t                                                                            <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <h2>Watch a video about anaphylaxis<\/h2>\n<h4>Anaphylaxis explained<\/h4>\n<p>This video will help you learn more about the potential risk of anaphylaxis with PALYNZIQ and how your care team will ensure you know how to respond if it happens.<\/p>\n                                                                                                                                                                                                                                                                                                                                                                                                                                                                        <p><a class=\"button button-arrow\" href=\"https:\/\/palynziq.biomarin.com\/en-us\/patient-stories\/\" target=\"_self\">Watch more videos about PALYNZIQ<\/a><\/p>\n                                                                                                                        <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"REMS\" class=\"block wrapped-content bg-band bg-band-secondary\" style=\"\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-699f1235045d2\" class=\"block-wysiwyg\">\n            <h2>The PALYNZIQ Risk Evaluation and Mitigation Strategy (REMS)<\/h2>\n<p>You can get PALYNZIQ only through the PALYNZIQ REMS program. The purpose of the program is to ensure that you have been fully informed of the risk of anaphylaxis associated with taking PALYNZIQ, and that you understand this risk before you start treatment. Your clinic team can tell you more about PALYNZIQ REMS and help you enroll.<\/p>\n<p><a class=\"button button-arrow button-ghost\" href=\"https:\/\/www.palynziqrems.com\/#Main\" target=\"_blank\" rel=\"noopener\">Explore the program<\/a><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"common\" class=\"block wrapped-content bg-band bg-band-white block-zero-top block-zero-bottom block-remove-top-padding block-remove-bottom-padding\" style=\"\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<div id=\"acf-block-699ee56acb0a3\" class=\"block-wysiwyg\">\n            <h2 style=\"text-align: center\">Most side effects were mild or moderate\u2014even with a higher dose<\/h2>\n<p style=\"text-align: center\">Some adults and teens taking PALYNZIQ experienced side effects during treatment. Discuss them with your clinic team and keep in mind that these are not all the possible side effects of PALYNZIQ. Call your clinic team for medical advice about side effects.<\/p>\n<p>&nbsp;<\/p>\n    <\/div>\n\n<figure id=\"acf-block-699ee56acb48b\">\n    <div class=\"image image-responsive image-rounded image-align-left\">\n                    <div class=\"image-desktop\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/02\/Card.svg\" alt=\"\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"image-mobile\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/02\/Card-2.png?v=1.50\" alt=\"\" \/>\t\t\t<\/div>\n            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-699ee56acd2e5\" class=\"block split-content equal-bias bg-band bg-band-white block-zero-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <p><strong>Other common side effects in adults:<\/strong><\/p>\n<ul>\n<li>Headache<\/li>\n<li>Skin reactions that spread and last at least \u202814 days, such as itching, rash, or redness<\/li>\n<li>Nausea<\/li>\n<li>Stomach pain<\/li>\n<li>Vomiting<\/li>\n<li>Cough<\/li>\n<li>Throat pain<\/li>\n<\/ul>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <ul>\n<li>Itchiness<\/li>\n<li>Diarrhea<\/li>\n<li>Nasal congestion<\/li>\n<li>Fatigue<\/li>\n<li>Dizziness<\/li>\n<li>Anxiety<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<figure id=\"acf-block-699ee56acb48b\">\n    <div class=\"image image-responsive image-rounded image-natural-size image-align-center\">\n                    <div class=\"image-desktop\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/container.svg\" alt=\"\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"image-mobile\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/Card-5.png?v=1.50\" alt=\"\" \/>\t\t\t<\/div>\n            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-699ee9ce2cff0\" class=\"block-wysiwyg\">\n            <p><small>*This includes redness, itching, pain, bruising, rash, swelling, or tenderness.<br \/>\n<small><sup>\u2020<\/sup>Rates of the other common side effects may vary.<br \/>\n<small><sup>\u2021<\/sup>Episode rate per patient-year is defined as the total number of times a side effect occurred in the study population divided by the length of time patients were in each phase of treatment.<br \/>\n<small><sup>\u00a7<\/sup>Maintenance phase was when patients in the clinical studies reached a stable dose for 8 weeks.<\/small><\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-699ee56acd2e5\" class=\"block split-content equal-bias bg-band bg-band-white block-zero-top block-zero-bottom\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                                                                                                                                                                                                    \n                                                                                                                \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-responsive image-rounded\">\n                                                                                            <div class=\"image-desktop\">\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/15-tile-2.svg\" alt=\"\" \/>                                                <\/div>\n                                                <div class=\"image-mobile\">\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/adults-taking-pal-1-1.svg\" alt=\"\" \/>                                                <\/div>\n                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                                                                                                                                                                                                    \n                                                                                                                \n                                                                                                                \n                                    \n                                    <figure>\n                                        <div class=\"image image-responsive image-rounded\">\n                                                                                            <div class=\"image-desktop\">\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/adults-common-side-effects-1.png?v=1.50\" alt=\"\" \/>                                                <\/div>\n                                                <div class=\"image-mobile\">\n                                                    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/adults-studies-1-1.svg\" alt=\"\" \/>                                                <\/div>\n                                                                                    <\/div>\n                                                                            <\/figure>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-69a70295ce837\" class=\"block wrapped-content bg-band bg-band-primary block-zero-top\" style=\"\">\n    <div class=\"wrapper\">\n        <div class=\"inner-wrapper\">\n                \n<figure id=\"acf-block-699ee9ce2d306\">\n    <div class=\"image image-responsive image-rounded image-align-left\">\n                    <div class=\"image-desktop\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/02\/Card-1.svg\" alt=\"\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"image-mobile\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/02\/Card-6.png?v=1.50\" alt=\"\" \/>\t\t\t<\/div>\n            <\/div>\n    <\/figure>\n\n<figure id=\"acf-block-699ee9ce2d306\">\n    <div class=\"image image-responsive image-rounded image-align-left\">\n                    <div class=\"image-desktop\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/Teens-experienced-fewer-callout-D-1900x307.jpg\" alt=\"\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"image-mobile\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/Teens-experienced-fewer-callout-M.png?v=1.50\" alt=\"\" \/>\t\t\t<\/div>\n            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-699ee56acd2e5\" class=\"block split-content equal-bias bg-band bg-band-primary block-zero-top block-tight-bottom block-remove-top-padding block-remove-bottom-padding\" data-muted-autoplay=\"false\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t                                                                <div class=\"content-block first-block\">\n                                                                                                <p><strong>Other common side effects in teens:<\/strong><\/p>\n<ul>\n<li>Hypersensitivity reactions<\/li>\n<li>Fever<\/li>\n<li>Dizziness<\/li>\n<li>Nausea<\/li>\n<\/ul>\n                                                                                    <\/div>\n                    \n                                            <div class=\"content-block second-block\">\n                                                                                                <ul>\n<li>Vomiting<\/li>\n<li>Fatigue<\/li>\n<li>Pain in the arms, hands, legs, or feet<\/li>\n<\/ul>\n                                                                                    <\/div>\n                                                \t\t<\/div>\n\t<\/div>\n<\/div>\n\n<figure id=\"acf-block-699ee56acd384\">\n    <div class=\"image image-responsive image-rounded image-align-left\">\n                    <div class=\"image-desktop\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/02\/teens-experience-treatment.png?v=1.50\" alt=\"\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"image-mobile\">\n\t\t\t    <img decoding=\"async\" class=\"\" src=\"https:\/\/palynziq.biomarin.com\/en-us\/wp-content\/uploads\/sites\/3\/2026\/03\/less-teens-1.svg\" alt=\"\" \/>\t\t\t<\/div>\n            <\/div>\n    <\/figure>\n\n<div id=\"acf-block-699ee56acd3c1\" class=\"block-wysiwyg\">\n            <h2 style=\"text-align: center\">Serious infections at the injection site have happened in people during treatment<\/h2>\n<p style=\"text-align: center\">Change (rotate) your injection site and check your injection site for redness, swelling, or tenderness before each injection. Tell your healthcare provider right away if you develop signs or symptoms of an infection at your injection site that are new, do not go away, or get worse.<\/p>\n    <\/div>\n        <\/div>\n    <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-10697","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Potential Side Effects - BioMarin Palynziq Patient EN-US<\/title>\n<meta name=\"description\" content=\"When you start treatment with PALYNZIQ, your immune system won\u2019t know what it is and may react to it. 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