{"id":10691,"date":"2026-01-20T16:05:46","date_gmt":"2026-01-20T16:05:46","guid":{"rendered":"https:\/\/palynziqpatient-prod-001.azurewebsites.net\/en-us\/?page_id=10691"},"modified":"2026-04-07T11:04:38","modified_gmt":"2026-04-07T11:04:38","slug":"how-palynziq-works","status":"publish","type":"page","link":"https:\/\/palynziq.biomarin.com\/en-us\/how-palynziq-works\/","title":{"rendered":"How PALYNZIQ Works Differently"},"content":{"rendered":"
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PALYNZIQ works differently than any other medicine\u2014across PKU types<\/h1>\n <\/div>\n\n
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It addresses the core of PKU\u2014by substituting for the PAH enzyme that is missing or not working properly.<\/h3>\n

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No matter how little PAH enzyme you have, PALYNZIQ can help to break down Phe<\/h4>\n <\/div>\n\n\n
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Did you know?<\/p>\n\n \"\" <\/div>\n \n

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2 OUT OF 3 PEOPLE WITH PKU<\/span> have no PAH enzyme or very little PAH enzyme. This is called CLASSICAL PKU.<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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Most oral PKU medicines try to help the PAH enzyme work better. However, these medicines often do not work for people with classical PKU.
\nEven if you respond to oral PKU medicines, they usually still require a restricted diet.<\/span><\/p>\n <\/div>\n\n

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PALYNZIQ IS THE FIRST AND ONLY FDA-APPROVED TREATMENT THAT SUBSTITUTES FOR THE PAH ENZYME<\/h3>\n \n

It is proven to lower Phe levels whether you have classical PKU or non-classical PKU, and does not require a restricted diet.<\/p>\n \n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n <\/div>\n <\/div>\n<\/div>\n\n

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It\u2019s time to reach the Phe levels\u2028you\u2019ve been working toward.<\/p>\n \n <\/div>\n

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View the study results<\/a><\/p>\n <\/div>\n<\/div>\n\n

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People like you share how they reached their treatment goals with PALYNZIQ.<\/p>\n \n <\/div>\n

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Watch now<\/a><\/p>\n <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n <\/div>\n <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-10691","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nHow PALYNZIQ Works Differently - BioMarin Palynziq Patient EN-US<\/title>\n<meta name=\"description\" content=\"PALYNZIQ works differently than any other medicine\u2014across PKU types. 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