about PALYNZIQIn our Real Talk video series, you can hear what taking PALYNZIQ is like from people who’ve been in your shoes. Honest discussions. Real perspectives.
Real Talk: Watch adults with PKU share how their PALYNZIQ injection fits into their daily schedules.
Please see Important Safety Information, including important warning for risk of anaphylaxis, and accompanying full Prescribing Information and Medication Guide.
Real Talk: Hear from adults with PKU taking PALYNZIQ about the process of lowering blood Phe levels.
Real Talk: Listen to how real adults with PKU open up about how they stayed on track throughout their journey to lower blood Phe levels.
Real Talk: Hear about some of the possible side effects on the journey to lower blood Phe levels.
For people like Leah, Kenneth, Sarah, and Kellen, lower Phe levels have changed many aspects of their lives. Watch each of their stories to learn more about how they have come to manage PKU with PALYNZIQ.
See how PALYNZIQ helped Leah lower her blood Phe levels.
Please see Important Safety Information, including important warning for risk of anaphylaxis, and accompanying full Prescribing Information and Medication Guide.
Learn about Kenneth’s life-long journey with PKU and how PALYNZIQ has helped.
Hear how Sarah has integrated PALYNZIQ into her daily life.
For young adults like Kellen, starting treatment as early as 18 years old can help lower blood Phe levels during the transition to adulthood.
PALYNZIQ is a treatment that helps people with PKU lower their blood Phe levels. These videos may help you better understand PALYNZIQ as you begin treatment.
Learn how the immune system responds to PALYNZIQ and how you’ll be supported as you work toward lowering your blood Phe levels.
Please see Important Safety Information, including important warning for risk of anaphylaxis, and accompanying full Prescribing Information and Medication Guide.
Watch this video for key information about PALYNZIQ and support from BioMarin RareConnections™.
Learn about injecting and administering PALYNZIQ with this step-by-step video.
Get more comfortable with needles and injections with a brief overview of the product, education, and support that you’ll receive when taking PALYNZIQ.
Learn more about the potential risk of a severe allergic reaction with PALYNZIQ injection.
What is the most important information I should know about PALYNZIQ?
PALYNZIQ can cause a severe allergic reaction (anaphylaxis) that may be life threatening and can happen any time during treatment with PALYNZIQ.
Severe allergic reactions are a serious but common side effect of PALYNZIQ.
Stop injecting PALYNZIQ and get emergency medical care right away if you have any of the following symptoms:
Keep the auto-injectable epinephrine with you at all times during treatment with PALYNZIQ. Read the Patient Information that comes with the auto-injectable epinephrine that your healthcare provider prescribes for you for more information.
If you have a severe allergic reaction, do not continue to take PALYNZIQ until you talk with your healthcare provider. Your healthcare provider will tell you if you can continue treatment with PALYNZIQ.
People taking PALYNZIQ have also experienced allergic reactions other than anaphylaxis. Talk to your healthcare provider if you experience any allergic reactions when taking PALYNZIQ.
PALYNZIQ REMS: PALYNZIQ is available only through a restricted program called the PALYNZIQ REMS (Risk Evaluation and Mitigation Strategy). Talk to your healthcare provider about the PALYNZIQ REMS and how to enroll.
What should I tell my healthcare provider BEFORE starting PALYNZIQ?
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Before injecting PALYNZIQ, talk to your healthcare provider right away if you cannot or will not use auto-injectable epinephrine to treat a severe allergic reaction. If you are pregnant or plan to become pregnant while taking PALYNZIQ, talk to your healthcare provider to discuss the risks and benefits of taking PALYNZIQ during pregnancy to you and your unborn baby. If you are breastfeeding or plan to breastfeed, talk to your healthcare provider about the best way to feed your baby if you take PALYNZIQ.
Before injecting PALYNZIQ, read the Medication Guide and Instructions for Use that come with your PALYNZIQ injection.
What should I watch for AFTER starting PALYNZIQ?
PALYNZIQ may cause serious side effects, including:
The most common side effects of PALYNZIQ include injection site reactions (such as redness, itching, pain, bruising, rash, swelling, or tenderness), joint pain, headache, skin reactions that spread and last at least 14 days (such as itching, rash, or redness), nausea, stomach pain, vomiting, cough, mouth and throat pain, itching, diarrhea, stuffy nose, feeling very tired, dizziness, anxiety, and low levels of Phe in your blood.
These are not all of the possible side effects of PALYNZIQ. Speak with your healthcare provider right away about any side effects.
Blood Phe testing and diet
Missed dose
Pregnancy Surveillance Program
You may report side effects to BioMarin at 1-866-906-6100.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information, including an important warning for risk of anaphylaxis, and the Medication Guide.
US-PAL-00519 02/25
What is the most important information I should know about PALYNZIQ?
PALYNZIQ can cause a severe allergic reaction (anaphylaxis) that may be life threatening and can happen any time during treatment with PALYNZIQ.
What is PALYNZIQ?
PALYNZIQ® (Pal-lin-zeek) (pegvaliase-pqpz) is a prescription medication used to lower blood levels of phenylalanine (Phe) in adults with PKU (phenylketonuria) who have uncontrolled blood Phe levels above 600 micromol/L (10 mg/dL) on their current treatment. You should discuss the potential benefits and risks of PALYNZIQ with your healthcare provider.