Where are you in your PALYNZIQ® (pegvaliase-pqpz) Injection treatment journey?
Get individualized education and support.
Are you struggling to lower your blood Phe levels? Here, you can find helpful information about PALYNZIQ and how it works. You can also hear from patients living with PKU and learn about their experience with PALYNZIQ
My husband and I realized that we needed to do something differently to manage my blood Phe levels.
Leah, taking PALYNZIQ
Learn more about PALYNZIQ, including information from its clinical trials and what to expect from your treatment.
Get the facts about the most common side effects experienced by patients during PALYNZIQ clinical trials
Explore live and virtual educational events where you can learn more about PALYNZIQ and connect with other adults who have PKU
Hear Leah’s story—from learning to live with PKU to discovering how PALYNZIQ could help lower her blood Phe levels
BioMarin Clinical Coordinators can offer 1-on-1 product support and education, help staying on track with your treatment plan, and ongoing education about PALYNZIQ.
Are you ready to talk with your healthcare team about whether PALYNZIQ may be right for you? These resources can help you prepare for the conversation so you can get the answers you need
I went to my clinic and asked my doctor questions about what it was and how it worked.
Sarah, taking PALYNZIQ
Learn more about PALYNZIQ, including information from its clinical trials and what to expect from your treatment
Get the facts about the most common side effects experienced by patients during PALYNZIQ
BioMarin Clinical Coordinators can offer 1-on-1 product support and education, help staying on track with your treatment plan, and ongoing education about PALYNZIQ
Here, you can learn more about navigating the insurance process for PALYNZIQ, including co-pay and financial assistance options for eligible adults, and how to get 1-on-1 support from a BioMarin Case Manager
My RareConnections Case Manager helped me navigate the process of finding out whether PALYNZIQ; was covered by my insurance and figuring out the logistics of getting my treatment.
Lauren, taking PALYNZIQ®
Learn more about BioMarin RareConnectionsTM and how they help identify potential coverage and financial assistance options.
Learn about the PALYNZIQ Co-Pay Assistance Program and find out if you are eligible
Establishing and maintaining a treatment routine is an ongoing process—and it’s an important step in your PALYNZIQ treatment journey
Daily self-injections took some getting used to—the education and support about PALYNZIQ provided to me by my healthcare team and BioMarin Clinical Coordinator helped me get comfortable with self-injecting.
Franki, taking PALYNZIQ
Your first PALYNZIQ® (pegvaliase-pqpz) Injection is an important step in your treatment—and it’s natural to have questions about it. Prepare for your in-clinic injection by finding out what to expect during and after your visit
See a detailed breakdown of the self-injection process and how to make it part of your routine
Learn how practice and product education can help you become comfortable with self-injecting PALYNZIQ® (pegvaliase-pqpz) Injection
Understand why your dose will be slowly increased to help your body get used to PALYNZIQ® (pegvaliase-pqpz) Injection
Your doctor will slowly adjust your dose over time to help your body get used to PALYNZIQ® (pegvaliase-pqpz) Injection. Learn more about what a typical PALYNZIQ dosing schedule looks like to understand what to expect
Familiarize yourself with important reminders about self-injection, like where to inject and why rotating injection sites is important
It’s important to remember why you began your PALYNZIQ® (pegvaliase-pqpz) Injection treatment journey. Complete your PALYNZIQ “Why” Card to keep your goals front and center
For young adults like Kellen, starting treatment as early as 18 years old can help make PALYNZIQ® (pegvaliase-pqpz) Injection a part of their routine
BioMarin Clinical Coordinators can offer 1-on-1 product support and education, help staying on track with your treatment plan, and ongoing education about PALYNZIQ® (pegvaliase-pqpz) Injection
Side effects can occur with PALYNZIQ. PALYNZIQ may cause a severe allergic reaction (anaphylaxis) that may be life threatening and can happen any time during treatment with PALYNZIQ. Find out more about anaphylaxis, the most common side effects seen in clinical studies of PALYNZIQ, and what to do if you experience any of them
After my healthcare provider and my BioMarin Clinical Coordinator explained the signs and symptoms of anaphylaxis, I felt confident that I would be able to identify and respond if anaphylaxis ever occurred.
Mia, taking PALYNZIQ®
Get the facts about the most common side effects experienced by patients during PALYNZIQ® (pegvaliase-pqpz) Injection
BioMarin Clinical Coordinators can offer 1-on-1 product support and education, help staying on track with your treatment plan, and ongoing education about PALYNZIQ® (pegvaliase-pqpz) Injection
It may take time to achieve blood Phe levels within the expert-recommended range.* It’s important to stick to the dosing schedule your healthcare team has prescribed for you, and understand why PALYNZIQ works differently in everyone
*less than 6 mg/dL.
One thing about PALYNZIQ is that it takes some time for the body to get used to.
Kenneth, taking PALYNZIQ®
Understand why your dose will be slowly increased to help your body get used to PALYNZIQ® (pegvaliase-pqpz) Injection
Familiarize yourself with important reminders about self-injection, like where to inject and why rotating injection sites is important
BioMarin Clinical Coordinators can offer 1-on-1 product support and education, help staying on track with your treatment plan, and ongoing education about PALYNZIQ® (pegvaliase-pqpz) Injection
Managing your blood Phe levels is a lifelong process. You’ve reached an important milestone in that journey by making PALYNZIQ part of your routine. Maintaining the routine you’ve developed with your healthcare team is key to keeping your blood Phe levels in the expert-recommended range*
*less than 6 mg/dL.
PALYNZIQ has definitely helped me take a more active role in lowering my blood Phe levels.
Kellen, taking PALYNZIQ®
Explore live and virtual educational events where you can learn more about PALYNZIQ and connect with other adults who have PKU
It’s important to remember why you began your PALYNZIQ® (pegvaliase-pqpz) Injection treatment journey. Complete your PALYNZIQ “Why” Card to keep your goals front and center
BioMarin Clinical Coordinators can offer 1-on-1 product support and education, help staying on track with your treatment plan, and ongoing education about PALYNZIQ
What is the most important information I should know about PALYNZIQ?
PALYNZIQ can cause a severe allergic reaction (anaphylaxis) that may be life threatening and can happen any time during treatment with PALYNZIQ.
Severe allergic reactions are a serious but common side effect of PALYNZIQ.
Stop injecting PALYNZIQ and get emergency medical care right away if you have any of the following symptoms:
Keep the auto-injectable epinephrine with you at all times during treatment with PALYNZIQ. Read the Patient Information that comes with the auto-injectable epinephrine that your healthcare provider prescribes for you for more information.
If you have a severe allergic reaction, do not continue to take PALYNZIQ until you talk with your healthcare provider. Your healthcare provider will tell you if you can continue treatment with PALYNZIQ.
People taking PALYNZIQ have also experienced allergic reactions other than anaphylaxis. Talk to your healthcare provider if you experience any allergic reactions when taking PALYNZIQ.
PALYNZIQ REMS: PALYNZIQ is available only through a restricted program called the PALYNZIQ REMS (Risk Evaluation and Mitigation Strategy). Talk to your healthcare provider about the PALYNZIQ REMS and how to enroll.
What should I tell my healthcare provider BEFORE starting PALYNZIQ?
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Before injecting PALYNZIQ, talk to your healthcare provider right away if you cannot or will not use auto-injectable epinephrine to treat a severe allergic reaction. If you are pregnant or plan to become pregnant while taking PALYNZIQ, talk to your healthcare provider to discuss the risks and benefits of taking PALYNZIQ during pregnancy to you and your unborn baby. If you are breastfeeding or plan to breastfeed, talk to your healthcare provider about the best way to feed your baby if you take PALYNZIQ.
Before injecting PALYNZIQ, read the Medication Guide and Instructions for Use that come with your PALYNZIQ injection.
What should I watch for AFTER starting PALYNZIQ?
PALYNZIQ may cause serious side effects, including:
The most common side effects of PALYNZIQ include injection site reactions (such as redness, itching, pain, bruising, rash, swelling, or tenderness), joint pain, headache, skin reactions that spread and last at least 14 days (such as itching, rash, or redness), nausea, stomach pain, vomiting, cough, mouth and throat pain, itching, diarrhea, stuffy nose, feeling very tired, dizziness, anxiety, and low levels of Phe in your blood.
These are not all of the possible side effects of PALYNZIQ. Speak with your healthcare provider right away about any side effects.
Blood Phe testing and diet
Missed dose
Pregnancy Surveillance Program
You may report side effects to BioMarin at 1-866-906-6100.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information, including an important warning for risk of anaphylaxis, and the Medication Guide.
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What is PALYNZIQ?
PALYNZIQ® (Pal-lin-zeek) (pegvaliase-pqpz) is a prescription medication used to lower blood levels of phenylalanine (Phe) in adults with PKU (phenylketonuria) who have uncontrolled blood Phe levels above 600 micromol/L (10 mg/dL) on their current treatment. You should discuss the potential benefits and risks of PALYNZIQ with your healthcare provider.