Living with PKU can be challenging, but you’ve come to the right place to find support. BioMarin is committed to offering comprehensive support and resources for those living with PKU and taking PALYNZIQ® (pegvaliase-pqpz) Injection.
It’s normal to have a lot on your mind when you’re living with PKU. The last thing you need to worry about is making sure the treatment is covered by your insurance, or figuring out the logistics of getting your treatment.
That’s where BioMarin RareConnections™ Case Managers come in. Experienced Case Managers provide one-on-one support to address your unique product needs, including:
To learn more about BioMarin RareConnections, visit BioMarin-RareConnections.com/PALYNZIQ.
We’re here to help. For assistance, please call 1-866-906-6100 Monday-Friday, 8 AM – 8 PM (ET).
Your Clinical Coordinator will be there to support treatment education by helping you understand how to fit your PALYNZIQ treatment into your lifestyle.
BioMarin Clinical Coordinators are available to provide ongoing product support and education in person, by phone or text, or via email. More specifically, they will provide:
Stay connected with the PKU community.
Stay informed about PKU management by attending an event or watching a live event on Facebook. If you attend an in-person event, you can meet other people living with PKU, learn about PKU management, and build your circle of support.
99% of participating patients paid $0 out-of-pocket for their prescription*,†,‡
– The PALYNZIQ Co-Pay Assistance Program will cover all co-pay costs related to both your PALYNZIQ and auto-injectable epinephrine prescriptions, up to the annual maximum, for as long as you remain on therapy
– Eligible patients will receive 3 fills of auto-injectable epinephrine per year at no additional cost
You can get PALYNZIQ only through the PALYNZIQ REMS program.
The purpose of this is to ensure that you have been fully informed of the risk of anaphylaxis associated with taking PALYNZIQ, and that you understand this risk before you start treatment.
Your clinic team can tell you more about the PALYNZIQ REMS and help you enroll.
Find a healthcare provider who will help you get enrolled in the PALYNZIQ REMS
*Valid only for those with commercial insurance. Offer not valid for prescriptions eligible to be reimbursed, in whole or in part, by Medicare, Medicaid or any other federal or state program (including any state prescription drug assistance programs) (eg, VA, DoD, TriCare), for cash-paying patients, where product is not covered by patient’s commercial insurance, or where plan reimburses you for entire cost of your prescription drug. No claim for reimbursement of the out-of-pocket expense amount covered by the Program shall be submitted to any third-party payer, whether public or private. Offer is not valid where prohibited by law. Valid only in the United States and Puerto Rico. This program is not health insurance. Offer may not be combined with any other rebate, coupon, or offer. Co-payment assistance under the Program is not transferable. BioMarin Pharmaceutical Inc. reserves the right to rescind, revoke or amend the program without notice. Patient certifies responsibility for complying with applicable limitations, if any, of any commercial insurance and reporting receipt of program rewards, if necessary, to any commercial insurer. This program is subject to termination or modification at any time.
Provide your contact information to receive important news and updates about PALYNZIQ.
BioMarin RareConnections™ can help with understanding insurance coverage and more.
What is the most important information I should know about PALYNZIQ?
PALYNZIQ can cause a severe allergic reaction (anaphylaxis) that may be life threatening and can happen any time during treatment with PALYNZIQ.
Severe allergic reactions are a serious but common side effect of PALYNZIQ.
Stop injecting PALYNZIQ and get emergency medical care right away if you have any of the following symptoms:
Keep the auto-injectable epinephrine with you at all times during treatment with PALYNZIQ. Read the Patient Information that comes with the auto-injectable epinephrine that your healthcare provider prescribes for you for more information.
If you have a severe allergic reaction, do not continue to take PALYNZIQ until you talk with your healthcare provider. Your healthcare provider will tell you if you can continue treatment with PALYNZIQ.
People taking PALYNZIQ have also experienced allergic reactions other than anaphylaxis. Talk to your healthcare provider if you experience any allergic reactions when taking PALYNZIQ.
PALYNZIQ REMS: PALYNZIQ is available only through a restricted program called the PALYNZIQ REMS (Risk Evaluation and Mitigation Strategy). Talk to your healthcare provider about the PALYNZIQ REMS and how to enroll.
What should I tell my healthcare provider BEFORE starting PALYNZIQ?
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Before injecting PALYNZIQ, talk to your healthcare provider right away if you cannot or will not use auto-injectable epinephrine to treat a severe allergic reaction. If you are pregnant or plan to become pregnant while taking PALYNZIQ, talk to your healthcare provider to discuss the risks and benefits of taking PALYNZIQ during pregnancy to you and your unborn baby. If you are breastfeeding or plan to breastfeed, talk to your healthcare provider about the best way to feed your baby if you take PALYNZIQ.
Before injecting PALYNZIQ, read the Medication Guide and Instructions for Use that come with your PALYNZIQ injection.
What should I watch for AFTER starting PALYNZIQ?
PALYNZIQ may cause serious side effects, including:
The most common side effects of PALYNZIQ include injection site reactions (such as redness, itching, pain, bruising, rash, swelling, or tenderness), joint pain, headache, skin reactions that spread and last at least 14 days (such as itching, rash, or redness), nausea, stomach pain, vomiting, cough, mouth and throat pain, itching, diarrhea, stuffy nose, feeling very tired, dizziness, anxiety, and low levels of Phe in your blood.
These are not all of the possible side effects of PALYNZIQ. Speak with your healthcare provider right away about any side effects.
Blood Phe testing and diet
Missed dose
Pregnancy Surveillance Program
You may report side effects to BioMarin at 1-866-906-6100.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information, including an important warning for risk of anaphylaxis, and the Medication Guide.
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What is PALYNZIQ?
PALYNZIQ® (Pal-lin-zeek) (pegvaliase-pqpz) is a prescription medication used to lower blood levels of phenylalanine (Phe) in adults with PKU (phenylketonuria) who have uncontrolled blood Phe levels above 600 micromol/L (10 mg/dL) on their current treatment. You should discuss the potential benefits and risks of PALYNZIQ with your healthcare provider.